Reduction of Double-Strand mRNA in Process Development
Time: 12:30 pm
day: Day One Track B AM
Details:
- dsRNA is a fatal immunogenic impurity generated through mRNA IVT process
- Highlighting the importance to reduce the dsRNA to a safe range for large dose or repeated dose of mRNA-based therapeutics
- CATUG DS100 and DS20 platform emphasises different strategies to control dsRNA <100ng/mg or even <20ng/mg
