Vinylphosphonic Acid Modified Cap Analogs and Their Performance in mRNA Vaccines
Time: 2:30 pm
day: Day 1 Track 2 PM
Details:
- Development of Vinylphosphonic Acid Modified Cap GAG (CAP5011) and GAU (CAP1811)
- Synthesis of mRNA using CAP5011 and CAP1811, and encapsulation in LNP
- Testing of mRNA capped with CAP5011 and CAP1811, including protein expression, vaccine induced immune response in vivo and mRNA safety in NHP.
