An mRNA Knowledge Library: Deep Profiling of Wild Type & Modified T7 Polymerases & Their Impacts on IVT Performance
Time: 9:00 am
day: Day 2 AM
Details:
- A high throughput screening (HTS) workflow was developed to enable comprehensive evaluation of T7 polymerase as a critical raw material in mRNA production
- Total 4 of wild type and 16 of modified T7 polymerases were systematically evaluated via DOE based IVT optimizations and subsequently mRNA analytics
- A ranking system including mRNA production performance, supply chain, and cost analysis for each T7 polymerase was established to support RecBioPharm’s advanced mRNA technology platform
