Extracellular Vesicles (Exosomes) Spread the Lipid Nanoparticle(LNP)-mRNA Between Cells: Do Exosomes Change the Fate of mRNA-Vaccines in Recipients?
Time: 11:00 am
day: Day One Track A AM
Details:
- After internalization (endocytosis) of mRNA-LNPs, the mRNA of LNPs is repacked into exosomes via endosomal-exocytosis route and transported to neighbouring cells or distant organs
- All cells at the administered area do not receive mRNA directly from LNPs but part of the mRNA of LNPs is distributed by exosomes, thus, exosomes contribute to expression of proteins or antibodies from this mRNA
- Exosomes carrying the mRNA of LNPs, transport this mRNA to organs differently than delivery via LNPs themselves, both for function and inflammatory response