Adjuvant-Modified Lipid Nanoparticles for mRNA Vaccine Delivery
Time: 11:45 am
day: Day Two Track (TRANSLATIONAL DEVELOPMENT TRACK)
Details:
- Inclusion of adjuvants in the lipid nanoparticIe-based carrier is a promising strategy for increasing the potency of mRNA vaccines
- Partial substitution of LNP components with an adjuvant result in colloidally stable LNPs with high mRNA entrapment and transfection efficiency
- The adjuvant substitution strategy works well for a clinically relevant mRNA-LNP vaccine, demonstrating its translational potential
