Discovering Oligonucleotide Senotheraputics for the Diseases of Ageing

Time: 2:00 pm
day: Focus Day


  • Taking a deeper look at how RNA processing, a major component of molecular stress resilience which is a major driver of cellular senescence in multiple human tissue types
  • Identifying the points of intervention that can be targeted for restoration of correct mRNA processing
  • Examining a designed portfolio of oligonucleotide interventions exploiting these auto-regulatory loops to restore regulated splicing factor expression in senescent primary human cells and demonstrated that these can ameliorate multiple aspects of the senescent cell phenotype and attenuate markers of disease phenotypes
  • Addressing dysregulated mRNA processing in senescence provides an opportunity to target the causes of age-related disease at their roots, rather than their consequences